Explore Secondary Metabolite gene clusters and uncover new resistant targets

  • Screen secondary metabolite gene clusters for known targets
  • Find unique metabolism and resistance factors in SM gene clusters
  • Discover leads to novel antibiotic targets

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Novel target screening criteria


Evidence of inter-species horizontal transfer indicates potential advantage linked to resistance.


Un-common gene copy number highlights alternate version potentially involved in resistance.


Gene location in close proximity of predicted antibiotic cluster indicates potential self-resistance mechanism.

Secondary metabolite gene cluster prioritization

Known targets

Identify gene clusters that contain known antibiotic gene clusters: Automated target directed genome mining

Resistance factors

Scan gene clusters for resistance factors that have been identified using Resfams and/or custom user models

Unique metabolism

Highlight potential repurposed primary metabolism genes as well as Domains of Unknown Function (DUF) in gene cluster