Antibiotic Resistant Target Seeker

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Do any input files contain sequences from multiple species or come from a metagenome?

Yes, my file(s) contains sequences from multiple species

No, each file represents a single genome

Multi-Genome upload

* Minimal antiSMASH run on all files and genecluster families will be computed with BiG-SCAPE

* Privacy Notice: This tool is designed for research purposes only. Please do not upload any sensitive, proprietary, or personally identifiable data. By proceeding, you confirm that your uploaded data does not contain sensitive or proprietary information.

Uploaded genomes

Upload progress

NCBI Accession Number

Sequence(s)

One genome per sequence file. Limit 20 Genomes per run and maximum of 100Mb per upload. Tip: Hold Ctrl/Cmd to select multiple files at a time. Please upload genomes separately if you run into upload problems due to bad connection.

Existing Antismash Job

Job id

GenBank file (Antismash5_result.gbk)

General

Job Title

Reference set

Options

Duplication & BGC Proximity screen

Phylogeny screen (query must be same phyla as reference)

Resistance Model screen (scan for know resistance factors)

Domain of unknown function screen (DUF)

Exploration mode (robust search)

Save link in cookies (viewable in results page)

Advanced

HMM search mode:

Trusted Cutoff (TC) Noise Cutoff (NC) Explore 1 (90% NC) Explore 2 (75% NC) Explore 3 (50% NC)

*Cutoff method used for HMM detection. Thresholds defined by the curators of each HMM model where TC = lowest bit-score of proteins included in model and NC = highest bit-score of proteins not used in model

Custom Resistance Model(s) (hmmer v3 file)

Custom Core Gene Model(s) (hmmer v3 file)